Publications by authors named "M Pieraccioli"
Triple negative breast cancer (TNBC) is an aggressive type of breast cancer. While most TNBCs are initially sensitive to chemotherapy, a substantial fraction acquires resistance to treatments and progresses to more advanced stages. Here, we identify the spliceosome U2 small nuclear ribonucleoprotein particle (snRNP) complex as a modulator of chemotherapy efficacy in TNBC.
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- - Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis and features different molecular subtypes, particularly the basal-like subtype, which shows increased resistance to chemotherapy.
- - The study identifies a specific splicing signature tied to PDAC subtypes and highlights the splicing factor Quaking (QKI) as crucial for the basal-like characteristics and worse patient outcomes.
- - QKI promotes splicing events that enhance the aggressive, adaptable traits of PDAC cells, contributing to their ability to migrate and resist chemotherapy, especially in high-grade tumors and metastases.
Background: Medulloblastoma (MB) is the most common cerebellar malignancy during childhood. Among MB, MYC-amplified Group 3 tumors display the worst prognosis. MYC is an oncogenic transcription factor currently thought to be undruggable.
View Article and Find Full Text PDFBackground: High grade serous ovarian cancer (HGSOC) is highly lethal, partly due to chemotherapy resistance and limited availability of targeted approaches. Cyclin dependent kinases 12 and 13 (CDK12/13) are promising therapeutic targets in human cancers, including HGSOC. Nevertheless, the effects of their inhibition in HGSOC and the potential synergy with other drugs are poorly known.
View Article and Find Full Text PDFTranscription-associated cyclin-dependent kinases (CDKs) regulate the transcription cycle through sequential phosphorylation of RNA polymerase II (RNAPII). Herein, we report that dual inhibition of the highly homologous CDK12 and CDK13 impairs splicing of a subset of promoter-proximal introns characterized by weak 3' splice sites located at larger distance from the branchpoint. Nascent transcript analysis indicated that these introns are selectively retained upon pharmacological inhibition of CDK12/13 with respect to downstream introns of the same pre-mRNAs.
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