Publications by authors named "M Picardo"
Research over the last decade has revealed that the normally pigmented skin of patients with vitiligo is not normal at all, as evidenced by alterations in cutaneous morphology and modifications in cellular and metabolic functions that ultimately drive immune activation against melanocytes. Furthermore, nonlesional skin is in a state of subclinical inflammation until triggered by internal and/or external exposomal events. Therefore, targeting early processes that drive immune dysregulation in normally pigmented skin may avoid or reduce melanocyte loss.
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- * The review highlights how skin aging can lead to pigmentary disorders, such as hyperpigmentation (like melasma) and hypopigmentation (like vitiligo).
- * It discusses the mechanisms behind how aging affects skin pigmentation and proposes possible treatment strategies for managing skin aging and related pigmentary issues.
Article Synopsis
- Recent studies indicate a high prevalence of metabolic syndrome (MetS) in patients with vitiligo, suggesting a link between the two conditions due to shared underlying mechanisms like oxidative stress and genetic factors.
- Patients with vitiligo show significant alterations in triglyceride, cholesterol, and blood pressure levels, as well as increased LDL cholesterol and reduced folate and vitamin D levels.
- The study highlights inflammatory markers and metabolic imbalances in vitiligo patients, indicating the potential for developing new therapeutic strategies targeting these systemic metabolic changes.
Article Synopsis
- A study assessed the efficacy and safety of ritlecitinib, a JAK3/TEC inhibitor, in treating nonsegmental vitiligo among patients with different skin types over 24 weeks, involving 247 patients with light skin and 117 with dark skin.
- Results showed significant improvement in facial vitiligo scores after 24 weeks for both skin types, with a 15.2% change for light skin and 37.4% for dark skin, alongside continuous repigmentation through week 48.
- Additionally, the study noted variations in immune response markers related to skin type, suggesting that dark-skinned patients may respond to the treatment faster than those with light skin
The presence of PFAS in drinking water may pose a serious threat to human health. This study aims to determine the levels of these compounds and their precursors in water samples from a drinking water treatment plant (DWTP) located in l'Ampolla (Spain) and to assess their fate. Additionally, ten Spanish bottled waters were analyzed to compare the occurrence of PFAS in the mentioned matrices and in drinking water.
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