Publications by authors named "M Piantelli"
Article Synopsis
- Phytonutrients in foods are more effective when consumed together rather than individually; tomato is highlighted for its complex micronutrients that support prostate health better than single nutrients alone.
- A new tomato supplement, enriched with olive polyphenols and high in cis-lycopene, has shown strong antioxidant properties, and successfully reduced inflammation markers linked to prostate cancer in animal studies.
- Clinical trials demonstrated that the supplement improved urinary symptoms and quality of life in patients with benign prostatic hyperplasia, suggesting it could be a beneficial alternative or complement to existing treatments.
Background: Platelet dysfunctions are shared by cardiovascular diseases and a wide range of inflammatory diseases.
Aims: To determine the ability of a new whole tomato-based food supplement (WTBFS) containing carotenoid and olive polyphenols to inhibit platelet aggregation.
Methods: Aggregation was evaluated in platelet-rich plasma using microtiter plates and a plate reader.
Trop-2 is a transmembrane signal transducer that is overexpressed in most human cancers, and drives malignant progression. To gain knowledge on the higher-order molecular mechanisms that drive Trop-2 signaling, we applied next-generation sequencing, proteomics, and high-resolution microscopy to models and primary cases of human colorectal cancer (CRC). We had previously shown that Trop-2 induces a Ca signal.
View Article and Find Full Text PDFUropathogenic (UPEC) UTI89 is a well-characterized strain, which has mainly been used to study UPEC virulence during urinary tract infection (UTI). However, little is known on UTI89 key fitness-factors during growth in lab media and during UTI. Here, we used a transposon-insertion-sequencing approach (TraDIS) to reveal the UTI89 essential-genes for growth and fitness-gene-sets for growth in Luria broth (LB) and EZ-MOPS medium without glucose, as well as for human bacteriuria and mouse cystitis.
View Article and Find Full Text PDFWe recently reported that activation of Trop-2 through its cleavage at R87-T88 by ADAM10 underlies Trop-2-driven progression of colon cancer. However, the mechanism of action and pathological impact of Trop-2 in metastatic diffusion remain unexplored. Through searches for molecular determinants of cancer metastasis, we identified TROP2 as unique in its up-regulation across independent colon cancer metastasis models.
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