Publications by authors named "M Pfister"
Article Synopsis
- Semi-automated surveillance systems effectively reduce time spent on monitoring non-ventilator hospital-acquired pneumonia (nvHAP) by using computer algorithms to identify at-risk patients for further manual review.
- * The study evaluated multiple nvHAP indicators and algorithms on a large cohort, examining their sensitivity, workload reduction, and efficiency in detecting cases based on a reference standard.
- * Results showed that complex algorithms significantly lowered the number of patients needing manual review by up to 96.2% while maintaining a high sensitivity of 92%, suggesting a promising method for improving patient surveillance in hospitals.
Low-dimensional neural ordinary differential equations accounting for inter-individual variability implemented in Monolix and NONMEM.
CPT Pharmacometrics Syst Pharmacol
November 2024
Article Synopsis
- * The implementation of low-dimensional NODEs in popular PMX software, Monolix and NONMEM, is detailed, highlighting inter-individual variability and practical applications.
- * Demonstrational datasets in Monolix show that NODEs can produce results comparable to traditional modeling techniques, with accessible model codes provided for reproducibility.
Article Synopsis
- * The study used continuous glucose monitoring data from a sports camp to assess the risk of nighttime hypoglycemia in children with T1D, employing machine learning models like random forest and deep neural networks.
- * Findings showed that the random forest model had a sensitivity of 71.1% and specificity of 75.8% in predicting nocturnal hypoglycemia, which is essential for taking timely actions to minimize risks for these children and their families.
The efficacy of the combination therapy of albendazole and ivermectin against Trichuris trichiura infection is higher in Tanzania than in Côte d'Ivoire. This study therefore aimed to investigate the difference between the population pharmacokinetics (PK) at these study sites and to determine if an exposure-response analysis could explain the low efficacy of the combination therapy in Côte d'Ivoire. Twenty-four participants (aged 12-19 years) receiving single doses of ivermectin (200 µg/kg) and albendazole (400 mg) were included in the population PK modeling.
View Article and Find Full Text PDFBackground: Perivascular space (PVS) enlargement in ageing and Alzheimer's disease (AD) and the drivers of such a structural change in humans require longitudinal investigation. Elucidating the effects of demographic factors, hypertension, cerebrovascular dysfunction, and AD pathology on PVS dynamics could inform the role of PVS in brain health function as well as the complex pathophysiology of AD.
Methods: We studied PVS in centrum semiovale (CSO) and basal ganglia (BG) computationally over three to four annual visits in 503 participants (255 females; mean = 70.