Publications by authors named "M Pfeilstoecker"

Background: Myelodysplastic/myeloproliferative neoplasms (MDS/MPN) comprise several rare hematologic malignancies with shared concomitant dysplastic and proliferative clinicopathologic features of bone marrow failure and propensity of acute leukemic transformation, and have significant impact on patient quality of life. The only approved disease-modifying therapies for any of the MDS/MPN are DNA methyltransferase inhibitors (DNMTi) for patients with dysplastic CMML, and still, outcomes are generally poor, making this an important area of unmet clinical need. Due to both the rarity and the heterogeneous nature of MDS/MPN, they have been challenging to study in dedicated prospective studies.

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Article Synopsis
  • Lineage involvement and maturation arrest are important for predicting outcomes in myelodysplastic syndromes (MDS), but the roles of eosinophils and basophils have not been thoroughly studied.
  • In a study of 1008 MDS patients, both eosinophilia (high eosinophil count) and basophilia (high basophil count) were found to significantly reduce survival rates, although they did not affect leukemia-free survival.
  • The findings suggest that measuring eosinophils and basophils could improve prognostic evaluations in MDS, particularly in specific risk subgroups, thereby enhancing patient management.
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