Dietary Niche Variation in an Invasive Omnivore: The Effects of Habitat on Feral Pig Resource Use in Hawai'i.

Invasive omnivores may have profound impacts on ecological communities through diet selection, particularly when their functional roles differ from those in their native range. While the threat of feral pigs () to native plant communities in Hawai'i is well known, their trophic dynamics and the drivers of variation in their diet remain understudied. We investigated the feral pig trophic niche on Hawai'i Island using stable isotopes (C and N) and Bayesian mixing models to identify drivers of variation in resource use.

Education Research: Evaluating Medical Student Learning Preference and Its Relationship to Clerkship Satisfaction.

Background And Objectives: The Accreditation Council for Graduate Medical Education and the Association of American Medical Colleges' commitment to competency-based medical education (CBME) has shifted the medical education landscape. Education methods conducive to CBME are learner-centered and give educators the opportunity to develop a more personalized approach to curricular development and delivery. By understanding learning preferences, educators are better positioned to respond to the changing needs of students.

Segregated in Life and Death: Arnold R. Rich and the Racial Science of Tuberculosis.

Arnold Rich (1893-1968) was an acclaimed pathologist and the first Jewish department chair at the Johns Hopkins School of Medicine. In his landmark text, The Pathogenesis of Tuberculosis, Rich continued to advance the concept of racial susceptibility to tuberculosis a decade after mainstream medicine recognized that environmental factors fueled the disease. While Rich fits into the historical narrative that embedded categories of race facilitated scientific racism, two characteristics unique to Rich help to explain why he persisted.

ASCL1 Restrains ERK1/2 to Promote Survival of a Subset of Neuroendocrine Lung Cancers.

The transcription factor achaete-scute complexhomolog 1 (ASCL1) is a lineage oncogene that is central in growth and survival of the majority of small cell lung cancers and neuroendocrine (NE) non-small cell lung cancers (NSCLC) that express it. Targeting ASCL1, or its downstream pathways, remains a challenge. Small cell lung cancers and NSCLC-NE that express ASCL1 exhibit relatively low ERK1/2 activity, in dramatic contrast to NSCLCs in which the ERK pathway plays a major role in pathogenesis.

Jumonji histone demethylases are therapeutic targets in small cell lung cancer.

Small cell lung cancer (SCLC) is a recalcitrant cancer of neuroendocrine (NE) origin. Changes in therapeutic approaches against SCLC have been lacking over the decades. Here, we use preclinical models to identify a new therapeutic vulnerability in SCLC consisting of the targetable Jumonji lysine demethylase (KDM) family.