Laser Desorption-Ion Mobility Spectrometry of Explosives for Forensic and Security Applications.

Background: The detection of explosives in crime scene investigations is critical for forensic science. This study explores the application of laser desorption (LD) ion mobility spectrometry (IMS) as a novel method for this purpose utilising a new IMS prototype developed by MaSaTECH.

Methods: The LD sampling technique employs a laser diode module to vaporise explosive traces on surfaces, allowing immediate analysis by IMS without sample preparation.

Comparison of Two Chelator Scaffolds as Basis for Cholecystokinin-2 Receptor Targeting Bimodal Imaging Probes.

: Dual-modality probes, combining positron emission tomography (PET) with fluorescence imaging (FI) capabilities in a single molecule, are of high relevance for the accurate staging and guided resection of tumours. We herein present a pair of candidates targeting the cholecystokinin-2 receptor (CCK2R), namely [Ga]Ga-CyTMG and [Ga]Ga-CyFMG. In these probes, the SulfoCy5.

Laser Desorption of Explosives from the Surface of Different Real-World Materials Studied Using CCl-Dopant-Assisted Ion Mobility Spectrometry.

A highly efficient and sensitive ion mobility spectrometry (IMS) system with laser desorption sampling was applied for rapid explosive detection using different surface materials. This portable IMS detector, powered by a battery, offers mobility and is suitable for use in the field or combat zones. The laser desorption (LD) sampling of common explosives (Trinitrotoluene-TNT; Dinitrotoluenes-DNTs; Hexogene-RDX; pentaerythritol tetranitrate-PETN; plastic explosives-Compound 4 (C-4) and Semtex) on a wide range of common surface materials, such as metal, ceramic, plastic, glass, drywall, paper, wood, and textiles, was studied.

Automated Production of [Ga]Ga-Desferrioxamine B on Two Different Synthesis Platforms.

PET imaging of bacterial infection could potentially provide added benefits for patient care through non-invasive means. [Ga]Ga-desferrioxamine B-a radiolabelled siderophore-shows specific uptake by human-pathogenic bacteria like or and sufficient serum stability for clinical application. In this report, we present data for automated production of [Ga]Ga-desferrioxamine B on two different cassette-based synthesis modules (Modular-Lab PharmTracer and GRP 3V) utilising commercially obtainable cassettes together with a licensed Ge/Ga radionuclide generator.

Computational Design of Pore-Forming Peptides with Potent Antimicrobial and Anticancer Activities.

Peptides that form transmembrane barrel-stave pores are potential alternative therapeutics for bacterial infections and cancer. However, their optimization for clinical translation is hampered by a lack of sequence-function understanding. Recently, we have designed the first synthetic barrel-stave pore-forming antimicrobial peptide with an identified function of all residues.