CLINICAL AND PATHOLOGIC PRESENTATIONS OF YERSINIOSIS IN VARIOUS NONDOMESTIC SPECIES: AN INVESTIGATION OF OUTBREAKS FROM FOUR NORTH AMERICAN ZOOLOGICAL INSTITUTIONS.

Yersiniosis due to can be associated with high morbidity and mortality in various species and has been a cosmopolitan management challenge in zoological institutions. This gram-negative, environmental bacterium thrives in cold, wet conditions and poses a risk to zoo species. Outbreaks can be costly and impact conservation efforts through loss of threatened and endangered species.

Repurposing an epithelial sodium channel inhibitor as a therapy for murine and human skin inflammation.

Inflammatory skin disease is characterized by a pathologic interplay between skin cells and immunocytes and can result in disfiguring cutaneous lesions and systemic inflammation. Immunosuppression is commonly used to target the inflammatory component; however, these drugs are often expensive and associated with side effects. To identify previously unidentified targets, we carried out a nonbiased informatics screen to identify drug compounds with an inverse transcriptional signature to keratinocyte inflammatory signals.

Functional genotype-phenotype associations in recessive dystrophic epidermolysis bullosa.

Background: Genotype-phenotype associations in recessive dystrophic epidermolysis bullosa (RDEB) have been difficult to elucidate.

Objective: To investigate RDEB genotype-phenotype associations and explore a functional approach to genotype classification.

Methods: Clinical examination and genetic testing of RDEB subjects, including assessment of clinical disease by RDEB subtype and extent of blistering.