Publications by authors named "M Perez-Cruz"
Introduction: Fetal growth restriction (FGR) may affect placental transfer of key nutrients to the fetus, such as the fatty acid docosahexaenoic acid (DHA). Major facilitator superfamily domain containing 2A (MFSD2A) has been described as a specific DHA carrier in placenta, but its expression has not been studied in FGR. The aim of this study was to evaluate for the first time the placental MFSD2A levels in late-FGR pregnancies and the maternal and cord plasma DHA.
View Article and Find Full Text PDFAlthough FOXP3 regulatory T cells (Treg) depend on IL-2 produced by other cells for their survival and function, the levels of IL-2 in inflamed tissue are low, making it unclear how Treg access this critical resource. Here, we show that Treg use heparanase (HPSE) to access IL-2 sequestered by heparan sulfate (HS) within the extracellular matrix (ECM) of inflamed central nervous system tissue. HPSE expression distinguishes human and murine Treg from conventional T cells and is regulated by the availability of IL-2.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to determine how the duration of symptoms before lumbar microdiscectomy impacts recovery outcomes, including pain relief and return to work.
- Researchers analyzed data from 2408 patients categorized into three groups based on the length of time they experienced symptoms before surgery: under 3 months, 3 months to 1 year, and over 1 year.
- Results showed that patients who had surgery within 3 months of symptom onset had significantly better pain relief and overall functional improvement compared to those with longer symptom durations.
Article Synopsis
- Researchers studied how removing certain antibodies can enhance protection against Gram-negative bacterial infections, focusing on anti-αGal antibodies.
- In experiments with genetically modified mice lacking these antibodies, they found improved survival rates from bacterial sepsis and better bacterial killing capability in their serum.
- The study suggests that inhibiting anti-αGal antibodies in both mice and human serum can boost the immune response against dangerous bacteria, pointing to new ways to prevent infections.
Unlabelled: Previous reports suggest that cord blood biomarkers could serve as a prognostic tool for conotruncal congenital heart defects (CHD). We aimed to describe the cord blood profile of different cardiovascular biomarkers in a prospective series of fetuses with tetralogy of Fallot (ToF) and D-transposition of great arteries (D-TGA) and to explore their correlation with fetal echocardiography and perinatal outcome.
Methods: A prospective cohort study (2014-2019), including fetuses with isolated ToF and D-TGA and healthy controls, was conducted at two tertiary referral centers for CHD in Barcelona.