Publications by authors named "M Perch"

Objectives: Extravascular lung water (EVLW) precedes deterioration of pulmonary function. Current tools to assess EVLW in a setting of donor lung procurement and ex vivo lung perfusion (EVLP) are either subjective or not feasible. Therefore, a direCt Lung Ultrasound Evaluation (CLUE) has been introduced.

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Purpose: The Management of Post-transplant Infections in Collaborating Hospitals (MATCH) programme, initiated in 2011 and still ongoing, was created to 1) optimise the implementation of existing preventive strategies against viral infections in solid organ transplant (SOT) recipients and allogenic haematopoietic stem-cell transplant (HSCT) recipients and 2) advance research in the field of transplantation by collecting data from a multitude of sources.

Participants: All SOT and HSCT recipients at Copenhagen University Hospital, Rigshospitalet, are followed in MATCH. By February 2021, a total of 1192 HSCT recipients and 2039 SOT recipients have been included.

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Background: Although the demand for allografts continuously surpasses the supply, the majority of lungs offered for transplant are declined based on various factors, including donor age. This in turn sustains the wait-list mortality of patients with end-stage pulmonary disease.

Methods: In this single-center, observational cohort study, we investigated the impact of donor age on graft survival.

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Article Synopsis
  • Vaccination before solid organ transplantation (SOT) is essential because immunosuppression post-transplant affects vaccine responses, but not much is known about how effective these vaccines are afterward.
  • In a study of 136 SOT recipients, only 27.9% showed protection against hepatitis B virus (HBV) and 42.6% against invasive pneumococcal disease (IPD) after transplantation despite being vaccinated before the procedure.
  • Patients who had seroprotection when listed for transplantation were significantly less likely to have a non-response to both HBV and IPD, indicating that early vaccination is crucial for improving post-transplant outcomes.
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