Publications by authors named "M Peradotto"
Article Synopsis
- Streptococcus pneumoniae
- in Piedmont, Italy.
- * Data from 2008 to present showed that out of 2,076 strains collected, 21.9% were resistant to penicillin G and 40.3% to erythromycin, with an overall increased risk of penicillin-resistant infections across all age groups.
- * The findings indicate a significant rise in penicillin G-resistant pneumococcal disease particularly among infants and the elderly following vaccination implementation, while the SARS-CoV2 pandemic didn't show a significant impact on AMR
The reduction of antimicrobial susceptibility testing (AST) time-to-result is a central need, especially in sepsis treatment. The current automated rapid ASTs are still too expensive for many laboratories. We aimed to evaluate three pre-treatment methods for a same-day inoculation on both automated AST platforms available in our laboratory.
View Article and Find Full Text PDFBackground: Fosfomycin is an old bactericidal drug that has gained increasing interest in the last decade for its potential use in multi-drug resistant gram-negative infections. However, evidence on fosfomycin susceptibility testing reports a poor correlation between commercial methods vs. reference agar dilution (AD) for (EB).
View Article and Find Full Text PDFArticle Synopsis
- - The lack of a globally accepted breakpoint and reliable susceptibility testing methods limits the effectiveness of fosfomycin against certain bacterial infections.
- - A study compared three testing methods (disk diffusion, E-test, and automated broth microdilution) to the reference method (agar dilution) using 150 isolates, revealing varying levels of agreement and error rates among methods.
- - Disk diffusion and E-test showed better categorical agreement for higher concentrations of fosfomycin, while automated broth microdilution had the lowest error rate but overall poor agreement, indicating the need for more extensive research and definitive breakpoints for fosfomycin.
Purpose: The impact of SARS-CoV-2 pandemic on other pathogens is largely unknown. We aimed to compare the prevalence of vaccine-preventable invasive bacterial infections before and during the pandemic in Piedmont (Italy).
Methods: We defined the monthly incidence of S.