Publications by authors named "M Penas-Prado"
Article Synopsis
- Sleep-wake disturbances are prevalent among primary brain tumor patients, and this study explores the relationship between patient-reported outcomes (PROs) and data from smart wearables like Fitbits over a 4-week period.
- Fifty-four patients participated, wearing Fitbits to track their sleep patterns and completing various PROs at the start and end of the study, showing high compliance and reliability in the data collected.
- Results indicated that while some patients experienced significant improvements in sleep disturbance, a notable correlation was found between wake after sleep onset and sleep disturbance, highlighting a need for further research into sleep mechanics in this patient population.
Article Synopsis
- Solitary fibrous tumors (SFTs) of the central nervous system are uncommon and lack clear treatment guidelines, making them challenging to manage.
- A case study highlights the successful use of radiation and immunotherapy on a recurrent SFT, driven by mutations in DNA repair genes identified through next-generation sequencing.
- The findings suggest that detecting specific genetic mutations could help tailor treatment strategies for SFT patients, potentially improving outcomes.
Article Synopsis
- Cancer survival rates are improving overall, but have not increased for adolescents and young adults (ages 15-39), especially for those with brain tumors.
- The report details the unique histopathological differences of brain tumors in AYA compared to children and older adults, revealing an average incidence rate of 12.00 per 100,000 population from 2016 to 2020 and approximately 1,018 deaths annually due to primary malignant brain tumors.
- The most common brain tumors were pituitary tumors, with an incidence that varied by race and sex, showing higher rates in females and distinct patterns among different racial/ethnic groups.
Purpose: Multidisciplinary tumor boards (MTBs) integrate clinical, molecular, and radiological information and facilitate coordination of neuro-oncology care. During the COVID-19 pandemic, our MTB transitioned to a virtual and multi-institutional format. We hypothesized that this expansion would allow expert review of challenging neuro-oncology cases and contribute to the care of patients with limited access to specialized centers.
View Article and Find Full Text PDFBackground: Glioblastoma (GBM) is the most aggressive primary brain malignancy with <45% living a year beyond diagnosis. Previously published investigations of long-term survivors (LTS) provided clinical data but rarely incorporated a comprehensive clinical and molecular analysis. Herein, we identify clinical, imaging, molecular, and outcome features for 23 GBM-LTS patients and compare them with a matched cohort of short-term survivors (STS).
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