Publications by authors named "M Pena-Rodriguez"
Polycystic ovary syndrome (PCOS) is the main endocrine disorder in women of reproductive age worldwide. This condition is often associated with various metabolic alterations that contribute to the development of metabolic syndrome (MetS). Recent research suggests that branched-chain amino acid (BCAA) dysregulation is observed in PCOS.
View Article and Find Full Text PDFGut microbiota disturbances may influence cognitive function, increasing uremic toxins and inflammation in dialysis patients; therefore, we aimed to evaluate the association of the gut microbiota profile with cognitive impairment (CI) in patients on automated peritoneal dialysis (APD). In a cross-sectional study, cognitive function was evaluated using the Montreal Cognitive Assessment in 39 APD patients and classified as normal cognitive function and CI. The gut microbiota was analyzed using the 16S rRNA gene sequencing approach.
View Article and Find Full Text PDFArticle Synopsis
- TANGO1, TANGO1-Short, and cTAGE5 work together in a place inside cells called the endoplasmic reticulum exit sites (ERES) to help move large materials out of the cell.
- TANGO1-Short has a special part that can be changed to respond to light, making it easier to control how it connects to another helper protein called Sec23A.
- The study found that when the TANGO1-Short connects to Sec23A after the light is turned on, it organizes the cargo in a way that helps sort larger materials differently from smaller ones, making it easier for the cell to release them efficiently.
Microbial community control is crucial for maintaining homeostasis of the gut-liver axis in metabolic dysfunction-associated steatotic liver disease (MASLD). Here, we show that supplementation with a mixture of Mexican foodstuffs (MexMix)- (nopal), (cocoa) and (crickets)-enriches several beneficial taxa in MASLD mice and overweight/obese humans. Thus, MexMix induces an important prebiotic effect.
View Article and Find Full Text PDFUnraveling the non-fitness status of NK cells: Examining the NKp30 receptor and its isoforms distribution in HIV/HCV coinfected patients.
Mol Immunol
August 2024
Article Synopsis
- HIV/HCV coinfection leads to faster liver damage due to dysregulation of natural killer (NK) cells, which are important for blocking HCV replication and preventing fibrosis.
- In a study, HCV-infected patients showed more liver damage than those with HIV alone, with a notable decrease in NKp30 isoform A expression and other NK cell markers in HIV/HCV patients.
- Understanding these dysfunctional NK cell parameters in HIV and HCV patients can help develop new treatments to enhance NK cell activity and reduce liver damage.