Publications by authors named "M Pavkovic"
Article Synopsis
- - Chronic kidney disease (CKD) progression is linked to oxidative stress damaging the NO-sGC-cGMP signaling pathway, but runcaciguat is a new drug that can activate dysfunctional sGC and restore this signaling under such conditions.
- - In studies with ZSF1 rats (a model for CKD/DKD), runcaciguat significantly reduced proteinuria and improved kidney function compared to placebo over a 12-week period with varying doses.
- - The treatment also positively impacted metabolic markers, reducing high blood sugar levels (HbA1c), triglycerides, and cholesterol in obese ZSF1 rats, suggesting its potential as a kidney-protective treatment.
Diabetic kidney disease (DKD) is the most common cause of renal failure. Therapeutics development is hampered by our incomplete understanding of animal models on a cellular level. We show that ZSF1 rats recapitulate human DKD on a phenotypic and transcriptomic level.
View Article and Find Full Text PDFMicro-RNAs (miRNAs) are regulators of gene expression and play an important role in physiological homeostasis and disease. In biofluids, miRNAs can be found in protein complexes or in extracellular vesicles (EVs). Altered urinary miRNAs are reported as potential biomarkers for chronic kidney disease (CKD).
View Article and Find Full Text PDFVitamin D contributes to blood pressure (BP) regulation. We compared the association of BP in diabetic patients with either total vitamin D - the standard way of analyzing the vitamin D status - or free vitamin D, because only free vitamin D passes the cell membrane and interacts with the nuclear vitamin D receptor (VDR). An analytical cross-sectional study was conducted with 178 diabetic patients with impaired kidney function.
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