Publications by authors named "M Paulson"
Enhanced suppression of by a three-phage cocktail: genomic insights and kinetic profiling.
Antimicrob Agents Chemother
January 2025
is an understudied, gram-negative, aerobic bacterium that is widespread in the environment and increasingly a cause of opportunistic infections. Treating remains difficult, leading to an increase in disease severity and higher hospitalization rates in people with cystic fibrosis, cancer, and other immunocompromised health conditions. The lack of effective antibiotics has led to renewed interest in phage therapy; however, there remains a great need for well-characterized phages, especially against .
View Article and Find Full Text PDFObjectives: Mayo Clinic's hospital-at-home program, Advanced Care at Home (ACH), launched in 2020. While hospital-at-home literature reported safe and effective care for the general patient population and those with COVID, comparative outcomes between these two groups were unknown. The aim of this retrospective analysis was to compare the outcomes of COVID and non-COVID patients enrolled in ACH and evaluate if COVID patients can be safely treated in this setting.
View Article and Find Full Text PDFVaricella-zoster virus (VZV) infection typically presents as a mild, self-limiting illness in children but can be severe and life-threatening in adults, particularly those who are immunocompromised. Atypical presentations, including hemorrhagic, necrotizing, and bullous forms, can complicate diagnosis and lead to delays in appropriate treatment. We present a case of a disseminated bullous VZV infection in an immunocompromised patient with cancer.
View Article and Find Full Text PDFArticle Synopsis
- Rising antibiotic resistance has made treating infections from the bacterium STM difficult, especially in immunocompromised patients, leading to more severe diseases.
- Researchers collected and characterized 18 distinct phages from California wastewater to explore their potential against STM, hypothesizing that a combined phage cocktail would be more effective than individual phages.
- The study found that a three-phage cocktail significantly reduced bacterial growth, showed effectiveness against a large number of STM strains, and helped prevent the emergence of phage-resistant bacteria, indicating its promise as a treatment option for tough STM infections.
Background: Hospital-at-home has become a more recognized way to care for patients requiring inpatient hospitalization. At times, these patients may require escalation of care (transfer from home back to the brick-and-mortar (BAM) hospital for ongoing hospitalization care needs), a process that has not been extensively studied.
Objective: To evaluate what patient factors contribute to escalations of care in the hospital-at-home delivery model.