Taming Conformational Heterogeneity on Ion Racetrack to Unveil Principles that Drive Membrane Permeation of Cyclosporines.

Our study reveals the underlying principles governing the passive membrane permeability in three large methylated macrocyclic peptides (MeMPs): cyclosporine A (CycA), Alisporivir (ALI), and cyclosporine H (CycH). We determine a series of conformers required for robust passive membrane diffusion and those relevant to other functions, such as binding to protein targets or intermediates, in the presence of solvent additives. We investigate the conformational interconversions and establish correlations with the membrane permeability.

Molecular Selectivity in the Binding of Alkali Metals, Alkaline Earth Metals, First-Row Transition Metals, and Lanthanides with Cyclic Depsipeptides.

Beauvericin (BEA) and enniatins (ENN) are cyclic hexadepsipeptide mycotoxins known for their ionophoric activities across cell membranes. While their ability to selectively bind alkali ions to form binary complexes has been studied, their interaction with multivalent metal ions to form higher-order complexes remains less explored. We report the unique characteristics of the 1:2, M:BEA or ENN complexes with monovalent, divalent, and trivalent metal ions.

[Effects of pulmonary rehabilitation on dysfunctional respiratory patterns in patients with uncontrolled asthma].

Purpose: Dysfunctional breathing patterns (DAM) are deviations from physiologic breathing patterns. DAM seem to be associated with lower asthma control. To date, it is unclear what effect inpatient rehabilitation can have on this problem.

Can an educational intervention in the context of inpatient pulmonary rehabilitation improve asthma self-management at work? A study protocol of a randomized controlled trial.

Background: Asthma self-management (e.g., trigger avoidance or correct medication use) is a cornerstone of therapy.