Publications by authors named "M Patz"
Understanding the complex interactions between metabolism and the immune system ("metaflammation") is crucial for the identification of key immunomodulatory factors as potential therapeutic targets in obesity and in cardiovascular diseases. Cathelicidin antimicrobial peptide (CAMP) is an important factor of innate immunity and is expressed in adipocytes. CAMP, therefore, might play a role as an adipokine in metaflammation and adipose inflammation.
View Article and Find Full Text PDFAdeno-associated virus (AAV) vectors are among the most prominent viral vectors for gene therapy, and their investigation and development using high-throughput techniques have gained increasing interest. However, sample throughput remains a bottleneck in most analytical assays. In this study, we compared commonly used analytical methods for AAV genome titer, capsid titer, and transducing titer determination with advanced methods using AAV2, AAV5, and AAV8 as representative examples.
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- Complex karyotypes (CKTs) and highly complex karyotypes (hCKTs) are significant predictors of worse outcomes in chronic lymphocytic leukemia (CLL) when treated with chemoimmunotherapy, and their impact is further explored in venetoclax-based therapies.
- * In a study involving 895 patients, CKTs were linked to shorter progression-free survival (PFS) and overall survival (OS) in the CIT group, while hCKTs negatively affected PFS in the venetoclax group.
- * The findings suggest that karyotype analysis should be included in standard CLL diagnostics to better identify patients at high risk for poor treatment outcomes, supporting more personalized treatment approaches.
The neuropeptide small cardioactive peptide (SCP) plays an integrative role in exciting various motor programs involved in feeding and locomotion in a number of gastropod species. In this study, immunohistochemistry, using monoclonal antibodies against SCP, was used to localize SCP-like-immunoreactive neurons in the central nervous system, and map their connections to various tissues, in the nudibranch, . Approximately 28-36 SCP-like-immunoreactive neurons were identified in the brain, as well as one large neuron in each of the buccal ganglia.
View Article and Find Full Text PDFCAMP (Cathelicidin antimicrobial peptide) is synthesized and secreted by adipocytes and involved in adipose tissue (AT) innate immune response and host defense of subcutaneous AT against Gram positive bacteria. Data on the regulation of CAMP in obesity and during weight loss are scarce and reference values do not exist. Serum CAMP levels (ELISA) and AT gene expression levels (quantitative real time PCR) were investigated in two large and longitudinal (12 months) cohorts of severely obese patients undergoing either a low calorie diet (LCD; n=79) or bariatric surgery (BS; n=156).
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