Publications by authors named "M Passeggeri"
Article Synopsis
- The 15q11.2 deletion is linked to neurodevelopmental disorders and its clinical implications are challenging due to confusing literature surrounding it.
- This study aimed to determine the effect size of this deletion using meta-analysis of various case-control studies, revealing a decrease in IQ by 4.3 points among carriers.
- The findings suggested that while the deletion has some association with disorders like intellectual disabilities and epilepsy, it is not significant enough to warrant discussion in clinical settings, as it mostly shows mild effects.
It has been suggested that the dentate gyrus, particularly its new neurons generated via adult neurogenesis, is involved in memory acquisition and recall. Here, we trained rats in two types of Morris water maze tasks that are differentially associated with these two memory processes, and examined whether new neurons are differently affected by the two tasks performed during the second week of neuronal birth. Our results indicate that the task involving more opportunities to acquire new information better supports the survival of new neurons.
View Article and Find Full Text PDFCopy number variants (CNVs) are major contributors to genomic imbalance disorders. Phenotyping of 137 unrelated deletion and reciprocal duplication carriers of the distal 16p11.2 220 kb BP2-BP3 interval showed that these rearrangements are associated with autism spectrum disorders and mirror phenotypes of obesity/underweight and macrocephaly/microcephaly.
View Article and Find Full Text PDFImportance: The 16p11.2 BP4-BP5 duplication is the copy number variant most frequently associated with autism spectrum disorder (ASD), schizophrenia, and comorbidities such as decreased body mass index (BMI).
Objectives: To characterize the effects of the 16p11.