ANN uncertainty estimates in assessing fatty liver content from ultrasound data.

Background And Objective: This article uses three different probabilistic convolutional architectures applied to ultrasound image analysis for grading Fatty Liver Content (FLC) in Metabolic Dysfunction Associated Steatotic Liver Disease (MASLD) patients. Steatosis is a new silent epidemic and its accurate measurement is an impelling clinical need, not only for hepatologists, but also for experts in metabolic and cardiovascular diseases. This paper aims to provide a robust comparison between different uncertainty quantification strategies to identify advantages and drawbacks in a real clinical setting.

Reverse transcription as key step in RNA evolution with unnatural base pairs.

Unnatural base pairs (UBPs) augment the chemical diversity of artificial nucleic acids and can thus enable the generation of new aptamers and catalytic nucleic acids by selection. However, owing to a lack of methodologies, the reverse transcription of UBPs, a key step in RNA aptamer selection, has not been sufficiently characterized. Here, we present a series of versatile assays to investigate the reverse transcription of the TPT3:NaM base pair as a representative for hydrophobic unnatural base pairs.

The metaverse of violence.

The metaverse appears to be a composite concept and a complex environment from an ontological perspective and from a purely dimensional point of view. Exploring its defining features not only allows one to identify the nature and effects of the social relations existing therein, but also influences the legal reading of what it contains and produces. Bringing to light the peculiar characteristics of the metaverse-for which the dichotomy between "real" and "virtual" sounds outdated-this article emphasizes the urgency to rethink the traditional forms of interpretation and design of preventive and repressive measures to counter deviant and illegal phenomena of a violent nature.