Publications by authors named "M Pariali"
Background: Cutaneous melanoma (CM) is one of the most lethal tumors among skin cancers and its incidence is rising worldwide. Recent data support the role of microRNAs (miRNAs) in melanoma carcinogenesis and their potential use as disease biomarkers.
Methods: We quantified the expression of miR-146a-5p and miR-21-5p in 170 formalin-fixed paraffin embedded (FFPE) samples of CM, namely 116 superficial spreading melanoma (SSM), 26 nodular melanoma (NM), and 28 lentigo maligna melanoma (LMM).
Article Synopsis
- A study examined the ABCC2 c.3972C > T SNP gene polymorphism's link to primary liver cancer (PLC) risk, particularly in siblings, three of whom had Wilson disease.* -
- Two brothers with the SNP and Wilson disease developed PLC after exposure to asbestos and cigarette smoking, unlike their siblings without such exposures.* -
- The results suggest that the SNP and Wilson disease alone may not cause PLC; instead, a combination of genetic and environmental factors are necessary for liver cancer development, highlighting the need for more research.*
Article Synopsis
- Autosomal dominant polycystic kidney disease (ADPKD) is a common inherited disorder often linked to genetic variants in specific genes, necessitating advanced genetic testing for accurate diagnosis and treatment.
- The study proposes a next-generation sequencing (NGS) strategy to analyze ADPKD, which successfully identified causative genetic variants in 61.3% of 212 patients tested, revealing significant genetic diversity and previously unreported variants.
- Additionally, the NGS approach uncovered alternative diagnoses for some patients and highlighted important genotype-phenotype correlations, indicating that certain mutations can lead to more severe disease outcomes.
Introduction: Toxic acute liver failure can be fatal even after liver transplantation. Since there are data only in young rats, the aim of our study was to verify the effectiveness of the increase of oxygen to the liver by partial portal vein arterialization (PPVA) in elderly rats with acute liver failure induced by carbon tetrachloride (CCl) intoxication.
Methods: Twenty elderly (30 months) Sprague-Dawley rats underwent a CCl intoxication (5 mL/kg).
Unhealthy dietary patterns have been associated with colorectal cancer (CRC) onset while Mediterranean Diet (MD) has been proposed for CRC prevention. This study evaluated the effect of a Mediterranean Diet Mix (MD-MIX) on colonic tumors development in A/J mice fed a low-fat (LFD) or a high-fat western diet (HFWD), and injected with the procarcinogen azoxymethane (AOM). Forty A/J male mice were randomly assigned into four feeding arms (10 mice/arm; LFD, LFD-MD-MIX, HFWD, HFWD-MD-MIX) to be treated with AOM.
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