Toxicity of lanthanides on various fish cell lines.

The growing use of Lanthanides in new technologies has increased their anthropogenic releases into the aquatic environment over the last decades. However, knowledge on their ecotoxicological impacts is still incomplete, especially with regard to biological effects of Lanthanides mixtures and the possible regular variation in toxicity along the Lanthanides series. The present study evaluated the individual toxicity of all Lanthanides and the toxicity of mixtures of three of them, namely Neodymium (Nd), Gadolinium (Gd), and Ytterbium (Yb) on Danio rerio fibroblast-like cells (ZF4).

Impact of gadolinium-based contrast agents on the growth of fish cells lines.

The present study was the first approach conducted under environmental concentrations of Gd-DOTA and Gd-DTPA-BMA to assess cellular impacts of these compounds. Gd-DOTA (Gadoteric acid) is one of the most stable contrast agent, currently used as Dotarem formulation during Magnetic Resonance Imaging exams. The study was mainly performed on a Zebra Fish cell line (ZF4; ATCC CRL-2050).

Variations of anthropogenic gadolinium in rivers close to waste water treatment plant discharges.

Rare earth element (REE) concentrations were determined for 22 sites sampled during two water periods: high flow in winter and low flow in summer. Shale-normalized REE patterns of all samples displayed positive gadolinium (Gd) anomalies. They revealed a widespread contamination of anthropogenic Gd (Gd) from waste water treatment plant (WWTP) outputs to catchment areas used for drinking water.

Bioaccumulation of gadolinium in freshwater bivalves.

In this study, the presence of anthropogenic gadolinium (Gd) was evaluated in rivers, close to wastewater treatment plant outputs. Then, one site was selected for in situ experiments to assess the bioaccumulation of Gd in the digestive gland and in the gills of two bivalves (Dreissena rostriformis bugensis and Corbicula fluminea). For both organisms, the results suggested that the bioaccumulation of Gd can be observed when organisms are exposed in a geogenic and anthropogenic Gd mixture.

Investigating the emerging role of comparative proteomics in the search for new biomarkers of metal contamination under varying abiotic conditions.

This study aims at investigating the potential use of comparative proteomics as a multi-marker approach of metal contamination, taking into account the potential confounding effect of water temperature. The major objective was to identify combinations of proteins specifically responding to a given metal, even if included in a metal mixture. The diagnostic approach was performed via the comparative analysis of protein expression on spot mapping provided by adult males of Gammarus pulex (Amphipoda, Crustacea) respectively exposed to arsenate (As), cadmium (Cd) or a binary mixture of these metals (AsCd) at three realistic temperatures (5, 10 and 15°C).