Publications by authors named "M Paoletta"
Many Plasmodium genes remain uncharacterized due to low genetic tractability. Previous large-scale knockout screens have only been able to target about half of the genome in the more genetically tractable rodent malaria parasite Plasmodium berghei. To overcome this limitation, we have developed a scalable CRISPR system called P.
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- Magnesium (Mg) is essential for metabolic functions and muscle health, with low levels (hypomagnesaemia) linked to muscle diseases and impairments in neuromuscular diseases (NMDs).
- A scoping review analyzed 305 studies, ultimately highlighting 20 (4 preclinical and 16 clinical) that show Mg's significant impact on muscle tissue health and recovery.
- While Mg supplementation has benefits for muscle mass and strength, research specifically on its effects in NMDs is limited, suggesting a need for further studies to explore this potential link.
The challenge of pharmacotherapy for musculoskeletal pain: an overview of unmet needs.
Ther Adv Musculoskelet Dis
May 2024
Musculoskeletal disorders are characterized by several impairments, including pain, affecting muscles, bones, joints and adjacent connective tissue, resulting in temporary or permanent functional limitations and disability. Musculoskeletal pain is particularly prevalent worldwide and greatly impacts the quality of life, social participation and economic burden. To date, several issues persist about the classification of musculoskeletal pain and its management strategies and resources.
View Article and Find Full Text PDFThe sequential antifracturative treatment: a meta-analysis of randomized clinical trials.
Ther Adv Musculoskelet Dis
April 2024
Background: Subjects with a fragility fracture have an increased risk of a new fracture and should receive effective strategies to prevent new events. The medium-term to long-term strategy should be scheduled by considering the mechanisms of action in therapy and the estimated fracture risk.
Objective: A systematic review was conducted to evaluate the sequential strategy in patients with or at risk of a fragility fracture in the context of the development of the Italian Guidelines.