Publications by authors named "M Pannella"
Aims: Follicle-stimulating hormone (FSH) plays a fundamental role in reproduction stimulating ovarian folliculogenesis, Sertoli cells function and spermatogenesis. However, the recent identification of FSH receptor (FSHR) also in extra-gonadal tissues has suggested that FSH activity may not be limited only to fertility regulation, with conflicting results on the possible role of FSH in endothelial cells. The aim of this study was to investigate FSH role on endothelial function in Human Umbilical Vein Endothelial Cells (HUVECs).
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- Musculoskeletal sarcomas are rare and diverse tumors, making research and treatment challenging for scientists and healthcare providers.
- Traditional methods using mice for xenografting are increasingly limited due to ethical concerns and stricter regulations, leading researchers to seek alternative models like chick embryos and zebrafish.
- These alternative models offer benefits such as cost-effectiveness, ease of tracking tumor growth, and the potential for enhanced drug screening, suggesting that a combination of different models could improve research and understanding of these tumors.
Tissue-engineered implants for bone regeneration require consideration regarding their mineralization and vascularization capacity. Different geometries, such as biomimetic designs and lattices, can influence the mechanical properties and the vascularization capacity of bone-mimicking implants. Negative Embodied Sacrificial Template 3D (NEST3D) printing is a versatile technique across a wide range of materials that enables the production of bone-mimicking scaffolds.
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- Myxofibrosarcoma is a rare and aggressive soft tissue cancer that often recurs and becomes more severe with each recurrence, posing challenges for patients and clinicians alike.
- The study introduces a new cell line (MF-R 3) derived from a myxofibrosarcoma patient, which was thoroughly characterized using various biological tests to evaluate its tumor properties.
- The MF-R 3 cell line exhibits similar characteristics to the original tumor and has shown promising sensitivity to anthracycline drugs, making it a valuable model for further research and drug testing.
Myxofibrosarcoma (MFS) is a malignant soft tissue sarcoma (STS) that originates in the body's connective tissues. It is characterized by the presence of myxoid (gel-like) and fibrous components and typically affects patients after the fifth decade of life. Considering the ongoing trend of increasing lifespans across many nations, MFS is likely to become the most common musculoskeletal sarcoma in the future.
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