Publications by authors named "M Pangalos"
Article Synopsis
- The brain uses a process called hippocampal neuronal plasticity to help us learn and remember things, which involves changes in how brain cells connect with each other.
- A protein called midkine (Mdk) is important for the brain's development and memory, and when it's missing, some types of memory can be affected.
- In experiments with rats, scientists found that learning activities caused Mdk levels to rise quickly and that adding more Mdk helped improve their memory in tests, showing that Mdk plays a helpful role in how we learn and remember.
Article Synopsis
- Telomeres are protective caps on chromosomes, and their length is related to aging and diseases, prompting a study on telomere length in over 462,000 UK Biobank participants.
- Researchers created a new metric for measuring telomere length that improved understanding of its genetic control and identified 64 genetic variants and 30 genes linked to telomere length.
- Notably, many of these genes are involved in clonal hematopoiesis, which is linked to certain cancers, indicating a complex relationship between rare genetic variants and telomere length.
Background: To develop medicines that are safe and efficacious to all patients, clinical trials must enroll appropriate target populations, but imbalances related to race, ethnicity and sex have been reported. A comprehensive analysis and improvement in understanding representativeness of patient enrollment in industry-sponsored trials are key public health needs.
Methods: We assessed race/ethnicity and sex representation in AstraZeneca (AZ)-sponsored clinical trials in the United States (US) from 2010 to 2022, compared with the 2019 US Census.
Integrating human genomics and proteomics can help elucidate disease mechanisms, identify clinical biomarkers and discover drug targets. Because previous proteogenomic studies have focused on common variation via genome-wide association studies, the contribution of rare variants to the plasma proteome remains largely unknown. Here we identify associations between rare protein-coding variants and 2,923 plasma protein abundances measured in 49,736 UK Biobank individuals.
View Article and Find Full Text PDFBackground: This study aimed to evaluate AZD2816, a variant-updated COVID-19 vaccine expressing the full-length SARS-CoV-2 beta (B.1.351) variant spike protein that is otherwise similar to AZD1222 (ChAdOx1 nCoV-19), and AZD1222 as third-dose boosters.
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