Intracarotid chemotherapy with etoposide and cisplatin for malignant brain tumors.

Chemotherapy for tumors of the central nervous system has a limited efficacy presumably because of restricted blood-brain barrier permeability. The advantage of regional intra-arterial administration of anticancer drugs is an increased uptake during the first passage of the drugs through tumor capillaries. Twenty patients with high-grade astrocytomas (HGA) and 28 patients with metastatic brain tumors (MBT) received intracarotid/intravertebral infusion of etoposide and cisplatin.

Multilevel thoracic disk herniations: CT and MR studies.

Thoracic disk herniation is a disorder that can present clinically perplexing problems for physicians. The true incidence of thoracic disk herniation is difficult to assess with various authors reporting an incidence ranging between 0.15 and 1.