Publications by authors named "M Palmisani"
Article Synopsis
- The study investigates the effects of the dual FAAH/MAGL inhibitor AKU-005 on migraine pain in a rat model induced by nitroglycerin (NTG).
- Administration of AKU-005 reduced pain sensitivity and levels of calcitonin gene-related peptide (CGRP) and pro-inflammatory markers in brain areas but not in serum endocannabinoid levels.
- The findings suggest that AKU-005 may help relieve migraine pain by lowering CGRP production and related inflammation, independent of its effects on the endocannabinoid system.
Resistant migraine characterizes those patients who have failed at least three classes of migraine prophylaxis. These difficult-to-treat patients are likely to be characterized by a high prevalence of psychological disturbances. A dysfunction of the endocannabinoid system (ECS), including alteration in the levels of endocannabinoid congeners, may underlie several psychiatric disorders and the pathogenesis of migraines.
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- * A study was conducted to investigate the production of melatonin (ME) in very preterm infants, the metabolism of ME after oral treatment, and the impact on MDA concentrations over 15 days.
- * Results showed that while preterm infants couldn't produce measurable levels of ME initially, those who received ME treatment had significant increases in ME and its metabolite 6-OH-ME, but MDA levels remained relatively stable with a slight trend towards improvement in the ME group.
The objective of this study was to validate a novel assay using the volumetric absorptive microsampling (VAMS) technique combined with liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) for the determination of the antiseizure medication perampanel in saliva and its clinical applicability in patients with epilepsy. VAMS tips were loaded with 30 μL of saliva and dried for 60 min. Analytes were extracted with methanol.
View Article and Find Full Text PDFIncreased anandamide levels via fatty acid amide hydrolase (FAAH) inhibition can decrease the pronociceptive responses and inflammatory mediators in animal models of migraine. Here, we profile the pharmacological activity of the FAAH inhibitor JZP327A, a chiral 1,3,4-oxadiazol-2(3H)-one compound, in the mediation of spontaneous and nocifensive behaviour in the animal models of migraine based on nitroglycerin (NTG) administration. JZP327A (0.
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