Publications by authors named "M Paillard"
Background: Although the benefit of supportive care in the postcancer period is now well demonstrated, its implementation in the patient journey remains challenging. This article describes the development, since 2015 and in routine care, of supportive postcancer care comprising a multidisciplinary rehabilitation programme (MRP) based on exercise for patients with early breast cancer.
Methods: As part of quality control, we reviewed all patient files since the programme was implemented.
Article Synopsis
- RANTES (CCL5) is a chemokine involved in immune response and may play a role in diseases like atherosclerosis, but its importance during acute myocardial infarction (MI) is not well understood.
- The study analyzed 250 patients with ST-segment-elevation MI, tracking serum levels of RANTES over time and its correlation with major adverse cardiovascular events during a 12-month follow-up.
- Results showed that lower levels of RANTES were linked to a higher risk of major adverse cardiovascular events, suggesting that post-MI RANTES levels could serve as a useful prognostic marker for patients.
Article Synopsis
- The study investigates the role of IL-6 and MCP-1 cytokines, along with the STAT3 signaling pathway, in recruiting and activating macrophages during heart attacks (STEMI) using both human and mouse models.
- Cardiac cells release these cytokines under low oxygen conditions, leading to the activation of anti-inflammatory macrophages through the STAT3 pathway.
- The research finds that blocking IL-6, MCP-1, or the STAT3 pathway can decrease heart damage after a heart attack, suggesting that these anti-inflammatory macrophages may have negative effects in the early stages of STEMI.
Article Synopsis
- Type 2 diabetes (T2D) negatively impacts left ventricular (LV) remodeling and function in patients with severe aortic stenosis (AS), leading to worse cardiac outcomes despite similar AS severity compared to non-diabetics.
- The study combined clinical assessments and biological analyses between T2D and non-diabetic patients undergoing valve replacement, revealing significant differences in gene expression related to inflammation, cardiac hypertrophy, and mitochondrial function.
- Findings indicated that T2D is associated with reduced mitochondrial function and calcium signaling, contributing to adverse cardiac remodeling, which may inform future treatment strategies for these patients.