Publications by authors named "M Paganini"
Hyperbaric oxygen therapy (HBOT) is a non-invasive method of O2 delivery that induces systemic hyperoxia. Hyperbaric chamber consists of a pressure vessel and a compressed breathing gas supply, which can regulate internal pressure. The chamber delivers 100% O2 to patients according to predetermined protocols and is monitored by trained personnel.
View Article and Find Full Text PDFShort-term unloading experienced following injury or hospitalisation induces muscle atrophy and weakness. The effects of exercise following unloading have been scarcely investigated. We investigated the functional and molecular adaptations to a resistance training (RT) programme following short-term unloading.
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- The study examines how humans respond to the hostile environment of space, focusing on isolation, disrupted sleep patterns, and high stress levels during a simulated moon mission.
- Five healthy young participants lived in a habitat for a week, with their stress levels monitored through wearable devices and biological samples.
- Results showed increased oxidative stress and cortisol levels, reduced sleep quality, and more daily exercise, suggesting that psychological stress and lack of sleep could negatively affect performance in long-term space missions.
Background: Alcohol abuse is one of the most common causes of mortality worldwide. This study aimed to investigate the efficacy of a treatment in reducing circulating ethanol and oxidative stress biomarkers.
Methods: Twenty wine-drinking subjects were investigated in a randomized controlled, single-blind trial (ClinicalTrials.
Cerebral hemodynamic and systemic physiological changes in trained freedivers completing sled-assisted dives to two different depths.
Am J Physiol Regul Integr Comp Physiol
December 2024
Although existing literature covers significant detail on the physiology of human freediving, the lack of standardized protocols has hindered comparisons due to confounding variables such as exercise and depth. By accounting for these variables, direct depth-dependent impacts on cardiovascular and blood oxygen regulation can be investigated. In this study, depth-dependent effects on ) cerebral hemodynamic and oxygenation changes, ) arterial oxygen saturation ([Formula: see text]), and ) heart rate during breath-hold diving without confounding effects of exercise were investigated.
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