Publications by authors named "M Paal"
Article Synopsis
- * Five antibiotics were tested in an in vitro model of continuous veno-venous hemodialysis, simulating different patient scenarios to see how drug levels could be adjusted effectively during dialysis.
- * Results indicate that target-controlled dialysis can reliably adjust and maintain antibiotic concentrations at desired therapeutic levels throughout the treatment, suggesting it may improve patient outcomes in critical care settings.
Purpose: The correct and early diagnosis of an infection is pivotal for patients, especially if the patients are immunocompromised. Various infection markers are used in clinics with different advantages and disadvantages. The neutrophil-to-lymphocyte ratio (NLR) is a cost effective parameter easily obtained without further investments.
View Article and Find Full Text PDFIntroduction: Adsorption devices like CytoSorb® (CS) are increasingly used in critically ill patients. However, potential adverse effects have not been sufficiently investigated. The aim of this post hoc analysis of the monocentric prospective Cyto-SOLVE study was to examine albumin concentration and platelet count during the application of CS in intensive care unit (ICU) patients with different indications for CS therapy.
View Article and Find Full Text PDFBackground/objectives: Elexacaftor, tezacaftor, and ivacaftor (ETI) have significantly improved lung function in people with cystic fibrosis (pwCF). Despite exceptional improvements in most cases, treatment-related inter-subject variability and drug-drug interactions that complicate modulator therapy have been reported.
Methods: This retrospective analysis presents data on the serum concentration of ETI in our pwCF with full or reduced dosage from August 2021 to December 2023 via routine therapeutic drug monitoring (TDM).