Publications by authors named "M PORTILLO"
Highly prevalent comorbidities associated with metabolic syndrome, such as abdominal obesity, nonalcoholic fatty liver disease (NAFLD) and insulin-resistance/Type 2 diabetes (IR/T2D) share alterations in gut microbiota composition as a potential triggering factor. Recent studies put the attention in the potential usage of postbiotics (inactivated probiotics) on these metabolic alterations. This review summarizes the current evidence regarding the efficacy of postbiotic administration in both, preclinical and clinical studies, for the management of obesity, NAFLD and IR/T2D.
View Article and Find Full Text PDFBackground: Precision nutrition is based on the integration of individual's phenotypical and biological characteristics including genetic variants, epigenetic marks, gut microbiota profiles, and metabolite fingerprints as well as medical history, lifestyle practices, and environmental and cultural factors. Thus, nutriomics areas including nutrigenomics, nutrigenetics, nutriepigenetics, nutrimetabolomics, and nutrimetagenomics have emerged to comprehensively understand the complex interactions between nutrients, diet, and the human body's molecular processes through precision nutrition.
Summary: This document from the Ibero-American Network of Nutriomics and Precision Nutrition (RINN22;
Metabolic syndrome refers to the simultaneous occurrence of several disorders that have been associated with other co-morbidities, such as a pro-inflammatory state and non-alcoholic fatty liver disease. Nowadays, it is a growing public health problem that contributes to the development of non-communicable diseases, such as type 2 diabetes, cardiovascular disease, and cognitive deficits among others. Its incidence has been related to modifiable lifestyle factors, mainly dietary patterns and physical activity.
View Article and Find Full Text PDFMaternal Dietary Improvement or Leptin Supplementation During Suckling Mitigates the Long-Term Impact of Maternal Obesogenic Conditions on Inflammatory and Oxidative Stress Biomarkers in the Offspring of Diet-Induced Obese Rats.
Int J Mol Sci
November 2024
Article Synopsis
- - This study explores how a mother's diet while nursing affects inflammation and oxidative stress in their baby rats, particularly those whose mothers were obese from a high-fat diet.
- - Offspring from mothers who switched to a healthier diet during lactation showed better metabolic health, including lower body weight and inflammation markers.
- - Leptin supplementation during the suckling period improved metabolic indicators, with differing effects based on the mother's diet and the offspring's sex, highlighting the potential for dietary strategies to reduce the negative impacts of maternal obesity.
Oxidative stress and inflammation are widely recognised as factors that can initiate and facilitate the development of MAFLD. The aim of this study is to analyse the effect of low and high doses of var. peel extract (L-OD and H-OD, respectively) and var.
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