Copper suppresses hippocampus LTP in the rat, but does not alter learning or memory in the morris water maze.

The objective of our study was to determinate the effect of copper on long-term potentiation (LTP) in hippocampus slices and a learning test in the Morris Water Maze (MWM). A group of adult Wistar rats received intraperitoneal (ip) injections of 1 mg/kg of CuSO(4) dissolved in saline for 30 consecutive days (Cu.R).

Interference of chronically ingested copper in long-term potentiation (LTP) of rat hippocampus.

The objective of our study was to find the evidence of copper interaction in LTP, motivated by copper involvement in neurodegenerative illness, like Parkinson, Alzheimer and Amyotrophic Lateral Sclerosis, and we initiated the study of this element in the LTP. For this purpose we used hippocampus slices of rats chronically consuming copper dissolved in water (CuDR; n=26) and non-copper-consuming rats (CR; n=20). The CuDR rats received 8--10 mg/day during 20--25 days.

Copper interaction on the long-term potentiation.

The role of copper on the CA1 piramidal neurons and their sinaptic connections to the Schaffer's collateral was investigated using the field excitatory post-sinaptic potential (fEPSP). The same fEPSP was used to study copper effects on Long-term potentiation (LTP). We have found that copper 10 microM has an inhibitory action on the fEPSP.

Cancer surveillance in patients receiving long-term hemodialysis.

Background: Cancer incidence in patients submitted to chronic hemodialysis still remains a subject of debate: there is evidence for increased risk, but the results are still controversial. Adoption of a specific surveillance protocol would appear useful.

Materials And Methods: In our Department we prospectively followed patients subject to long-term hemodialysis for a 10-year period, having adopted strict inclusion criteria.

Donor and recipient postoperative complications in living related kidney transplantation. A multicentric study.

Background: Living related kidney transplantation is considered a gold standard of renal transplantation in order to overcome end-stage renal disease within the same family members. Living donation, albeit decreasing cadaveric donor shortage, exposes donors to the risk of surgical complications.

Methods: In order to assess the postoperative complication rate in donors and recipients, we reviewed retrospectively 90 consecutive living related kidney transplants in a multicentric study.