Publications by authors named "M P. Foschini"
Objectives: The aim of the present study was to analyze the methylation status in patients who presented with an Oral Squamous Cell Carcinoma (OSCC) concomitantly with multifocal Proliferative Verrucous Leukoplakia (PVL)(PVL-OSCC).
Methods: Nine patients with OSCC and concomitant PVL lesions were selected. Two brushing samples were collected simultaneously from OSCC and PVL lesions in contralateral mucosa from each patient.
Head and neck cancers (HNCs) arise from anatomically adjacent sites and subsites, with varying etiological factors, diagnostic strategies, prognoses, and treatment approaches. While conventional squamous cell carcinoma (SCC) is the most common histology in the head and neck district, HNCs encompass a variety of rare histopathological entities, categorized into epithelial tumors such as salivary gland cancers, sinonasal tumors, neuroendocrine tumors, malignant odontogenic tumors, and SCC variants versus non-epithelial tumors including soft tissue sarcomas, mucosal melanomas, and hematological malignancies. Rare HNCs (R-HNCs) represent a diagnostic and clinical challenge, requiring histopathological expertise, the availability of peculiar molecular analysis, and the personalization of local and systemic treatments, all guided by a multidisciplinary tumor board.
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- Heterotopia refers to the abnormal presence of salivary gland tissue in atypical locations during development, and malignant growths from these ectopic tissues are uncommon.
- A case study detailed a 66-year-old male with a neck mass, initially thought to be benign, which was later diagnosed as Secretory Carcinoma (SC) arising from heterotopic salivary gland tissue within a lymph node after surgical removal.
- This case is particularly significant as it highlights the rare occurrence of SC in heterotopic tissues, enhancing knowledge of how tumors in unusual sites behave similarly to those in normal salivary glands.
Article Synopsis
- Linear nevus sebaceous syndrome (LNSS) is a rare skin and neurological disorder that involves sebaceous nevi and other genetic lesions.
- Sialadenoma papilliferum (SP) is a rare benign tumor in the mouth, usually linked to mutations in BRAF or HRAS genes.
- This report presents a unique case of a young girl with LNSS who developed SP with a KRAS mutation, marking it as the first documented instance of this mutation related to LNSS.
Article Synopsis
- TP53 mutations are common in patients with IDH-wildtype GBM, but their impact on patient prognosis has not been well studied.
- This study analyzed 97 patients under 70 years old who received specific treatments and found that 19.4% had TP53 mutations, but this did not significantly affect overall survival rates.
- Although TP53 mutations didn't correlate with survival for all patients, they were linked to longer survival in a small group with overall survival over 36 months, indicating they might be important for certain long-term survivors.