Publications by authors named "M P Yavropoulou"
Background: Neuroendocrine neoplasms (NEN) are rare tumors arising from neuroendocrine cells most commonly in the gastrointestinal-tract. In recent years, advancements in therapeutics have increased survival rates in patients with NEN leading to a greater clinical burden compared to the general population.
Methods: The aim of this single-center case-control study was to investigate the incidence of low bone mass and changes in body composition in adult patients diagnosed with gastroenteropancreatic neuroendocrine tumors (GEPNET).
Article Synopsis
- - The report by the European Calcified Tissue Society (ECTS) outlines evidence-based recommendations for preventing and treating glucocorticoid-induced osteoporosis (GIOP) in adults, aimed at healthcare providers who may not specialize in bone health.
- - Experts reviewed the literature and created 25 recommendations that categorize patients based on their fracture risk: medium, high, and very high, considering factors like age and history of fractures for appropriate treatment strategy.
- - Key general measures include optimizing calcium and vitamin D intake, assessing fracture risk regularly for those on glucocorticoids for three months or longer, and minimizing fall risks among patients.
Importance: Osteoporotic vertebral compression fractures (VCFs) frequently cause substantial pain and reduced mobility, posing a major health problem. Despite the critical need for effective pain management to restore functionality and improve patient outcomes, the value of various conservative treatments for acute VCF has not been systematically investigated.
Objective: To assess and compare different conservative treatment options in managing acute pain related to VCF.
Primary hyperparathyroidism: from guidelines to outpatient clinic.
Rev Endocr Metab Disord
October 2024
Article Synopsis
- Primary hyperparathyroidism (PHPT) is an endocrine disorder causing high calcium levels due to excess parathyroid hormone, with common treatment being surgical removal of the overactive parathyroid gland.
- Diagnosis can be straightforward in symptomatic cases but is more complex in asymptomatic or normocalcemic forms, often requiring specialized imaging to locate the problematic tissue.
- The article uses clinical examples to detail the diagnostic process, investigative methods for different forms of PHPT, and outlines both surgical and conservative management approaches.
Background: Hypocortisolemia is associated with increased expression of NR3C1 (glucocorticoid receptor, GR) in blood cells. As endogenous cortisol production is decreased in some RA patients, we tested the hypothesis that GR may be aberrantly expressed in rheumatoid synovium.
Methods: We defined the cellular pattern of NR3C1 synovial expression using human and mouse single-cell RNA-sequencing data.