Publications by authors named "M P Yaffe"
Background: Long-term care (LTC) residents are a previously untested and highly vulnerable population at risk of elder abuse (EA) and its many negative health outcomes. The detection of elder abuse within the LTC context is urgent and time-sensitive.
Objective: The overarching aim of this study is to evaluate the feasibility of implementing the Elder Abuse Suspicion Index - long-term care (EASI-ltc): the first comprehensive detection tool of its kind designed specifically to identify the abuse of cognitively-apt persons living in LTC.
Purpose: We observed that the tumor microenvironment (TME) in metastatic epithelial ovarian cancer (EOC) and in other solid tumors can reprogram normal neutrophils to acquire a complement-dependent suppressor phenotype characterized by inhibition of stimulated T cell activation. This study aims to evaluate whether serum markers of neutrophil activation and complement at diagnosis of EOC would be associated with clinical outcomes.
Experimental Design: We conducted a two-center prospective study of patients with newly diagnosed EOC (N = 188).
Importance: Evolving breast cancer treatments have led to improved outcomes but carry a substantial financial burden. The association of treatment costs with the cost-effectiveness of screening mammography is unknown.
Objective: To determine the cost-effectiveness of population-based breast cancer screening in the context of current treatment standards.
Objective: This systematic review update synthesized recent evidence on the benefits and harms of breast cancer screening in women aged ≥ 40 years and aims to inform the Canadian Task Force on Preventive Health Care's (CTFPHC) guideline update.
Methods: We searched Ovid MEDLINE® ALL, Embase Classic + Embase and Cochrane Central Register of Controlled Trials to update our searches to July 8, 2023. Search results for observational studies were limited to publication dates from 2014 to capture more relevant studies.
Article Synopsis
- 5-fluorouracil (5-FU) is an important cancer treatment that mostly works by blocking a specific enzyme, leading to DNA damage, but clinical trials show it doesn't work well with certain other drugs for colorectal cancer.
- Research indicates that 5-FU actually kills colorectal cancer cells by targeting RNA during the process of making ribosomes, rather than mainly causing DNA damage, which some cancer types are more sensitive to.
- Strategies that increase ribosome production may enhance the effectiveness of 5-FU, suggesting that combining treatments that focus on this aspect could improve outcomes in cancer therapy.