Glucosylceramide Synthase Inhibition in Combination with Aripiprazole Sensitizes Hepatocellular Cancer Cells to Sorafenib and Doxorubicin.

Hepatocellular carcinoma () is one of the leading causes of cancer deaths due to its late diagnosis and restricted therapeutic options. Therefore, the search for appropriate alternatives to commonly applied therapies remains an area of high clinical need. Here we investigated the therapeutic potential of the glucosylceramide synthase (GCS) inhibitor Genz-123346 and the cationic amphiphilic drug aripiprazole on the inhibition of Huh7 and Hepa 1-6 hepatocellular cancer cell and tumor microsphere growth.

Clinically Implemented Sensing-based Initial Programming of Deep Brain Stimulation for Parkinson's Disease: A Retrospective Study.

Objectives: Initial deep brain stimulation (DBS) programming using a monopolar review is time-consuming, subjective, and burdensome. Incorporating neurophysiology has the potential to expedite, objectify, and automatize initial DBS programming. We aimed to assess the feasibility and performance of clinically implemented sensing-based initial DBS programming for Parkinson's disease (PD).

Emotion regulation use in daily-life and its association with success of emotion-regulation, self-efficacy, stress, and state rumination.

Introduction: Investigations on emotion regulation strategies (ERS) primarily focus on the influence of instructed emotion regulation (ER) on outcomes. However, recent work has shown that selection of ERS is dependent on, e.g.

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Unlabelled: Changes in conflict pathology during inpatient psychotherapy and their relationship with symptom reduction Background: In psychodynamic psychotherapy, the treatment of a patient's unconscious conflicts represents an essential aspect of psychotherapeutic success. The present study therefore investigated whether 1) the significance of conflict issues changes during inpatient psychodynamic psychotherapy, and whether 2) greater changes in the significance of conflicts are associated with a greater reduction in symptoms.

Method: 113 patients provided information on their symptoms (BSI-18) and the significance of six OPD conflict themes in active and passive mode (12 conflict scales) by self-report on admission and discharge.