Publications by authors named "M P Verhagen"
Article Synopsis
- The study aimed to evaluate the effectiveness of different treatments for hepatic artery stenosis (HAS) in children after liver transplantation.
- Conducted over nearly 20 years, it analyzed outcomes in 327 pediatric liver transplant patients, focusing on survival rates and complications associated with HAS.
- Results showed that both endovascular therapy (EVT) and conservative management led to high graft and patient survival rates, indicating good long-term outcomes for children with HAS after transplantation.
Article Synopsis
- Intra-tumor heterogeneity complicates cancer treatment by contributing to therapy resistance and disease recurrence, but its underlying mechanisms are not well understood.
- Researchers studied the SW480 colon cancer cell line to explore this diversity and found three distinct subpopulations: resident cancer stem cells (rCSCs), migratory CSCs (mCSCs), and high-relapse cells (HRCs).
- These subpopulations exhibit different levels of Wnt signaling and gene expression, and spatial transcriptomic data from patient tumors supports their existence and varying distribution in the tumor microenvironment.
Western lifestyle, metaflammation and the cell of origin of colon cancer.
Nat Rev Gastroenterol Hepatol
September 2024
Posterior Cervical Foraminotomy Compared with Anterior Cervical Discectomy with Fusion for Cervical Radiculopathy: Two-Year Results of the FACET Randomized Noninferiority Study.
J Bone Joint Surg Am
September 2024
Background: Posterior cervical foraminotomy (posterior surgery) is a valid alternative to anterior discectomy with fusion (anterior surgery) as a surgical treatment of cervical radiculopathy, but the quality of evidence has been limited. The purpose of this study was to compare the clinical outcome of these treatments after 2 years of follow-up. We hypothesized that posterior surgery would be noninferior to anterior surgery.
View Article and Find Full Text PDFAccording to conventional views, colon cancer originates from stem cells. However, inflammation, a key risk factor for colon cancer, has been shown to suppress intestinal stemness. Here, we used Paneth cells as a model to assess the capacity of differentiated lineages to trigger tumorigenesis in the context of inflammation in mice.
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