[Antimicrobial activity of nitrofurans (nitrofurantoin, furazidine and furazidine potassium) against uropatogenic Escherichia Coli isolated from patients with lower urinary tract infections].

Currently, the problem of antibiotic resistance is of great relevance to society not only for medical, but also for social and economic reasons. Infections caused by multidrug-resistant pathogens have a longer course, more often require hospitalization, and increase the risk of mortality. The antimicrobial resistance is most relevant for hospitals in the case of the development of nosocomial infections.

[Rationale for choosing an antibiotic for the treatment of cystitis: recommendations of clinical pharmacologists: A review].

In recent years, the harmonization of domestic and foreign clinical recommendations for the treatment of cystitis has been achieved. Nitrofurans and fosfomycin trometamol are recommended as first line therapy antibiotics, and oral 3rd generation of cephalosporins are recommended as alternative antibiotics; fluoroquinolones are excluded from the recommended medications due to an unfavorable safety profile. The main rationale for inclusion of antibiotics in the recommendations as a first line therapy of cystitis is the level of resistance of uropathogens to antibiotics, primarily Escherichia coli.

Screening of natural surface waters of the Almaty region of the Republic of Kazakhstan for toxic and mutagenic activity.

Natural aquatic ecosystems are a habitat for many organisms, a source of drinking water, and a resource for human economic activity. However, natural surface waters have been subjected to intense anthropogenic pressure in recent decades. The current study was dedicated to investigating genotoxic potential in 15 rivers and 2 lakes of Almaty agglomeration (Kazakhstan) using a battery of bioassays.

In Vitro Evaluation of the Cytotoxic Effect of Strains, Protegrin PG-1, Cathelicidin LL-37, Nerve Growth Factor and Chemotherapy on the C6 Glioma Cell Line.

Brain cancer treatment, where glioblastoma represents up to 50% of all CNS malignancies, is one of the most challenging calls for neurooncologists. The major driver of this study was a search for new approaches for the treatment of glioblastoma. We tested live , cathelicidin family peptides and NGF, assessing the oncolytic activity of these compounds as monotherapy or in combination with chemotherapeutics.

[Rationale for the choice of an antibiotic for urinary tract infections with an emphasis on the environmental safety of therapy].

Difficulties in prescribing antibiotics for lower urinary tract infections (UTI) are associated with a fact that such patients can be treated not only by urologists, but also by general practitioners, internists, pediatricians, and gynecologists. Therefore, it is important to adapt the practical recommendations for the treatment of cystitis for different medical disciplines. When creating clinical guidelines, experts take into account the different factors in choosing antibiotic therapy.