The Influence of KE and EW Dipeptides in the Composition of the Thymalin Drug on Gene Expression and Protein Synthesis Involved in the Pathogenesis of COVID-19.

Thymalin is an immunomodulatory drug containing a polypeptide extract of thymus that has demonstrated efficacy in the therapy of acute respiratory distress syndrome and chronic obstructive pulmonary disease, as well as in complex therapy related to severe COVID-19 in middle-aged and elderly patients.. KE and EW dipeptides are active substances of Thymalin.

L-Cysteine and -acetyl-L-cysteine-mediated synthesis of nanosilver-based sols and hydrogels with antibacterial and antibiofilm properties.

The need of the synthesis of a new generation of medicines aimed at combating bacteria and biofilms that cause various infections is a great urgency. There has been a gradual decrease in the conventional techniques of treatment with the use of antibiotics. Consequently, much effort has focused on the search for new methods and approaches to obtain antibacterial drugs and determine their rational use such that microorganisms do not acquire resistance.

[Distribution of after-penetration gunshot wound zones].

Aim of this study is to establish the distance and spacing of gunshot wound in the conditions of after-penetration target location. The experimental studies series on shooting coarse colico targets located behind a triplex (car windshield) with record of results by a high-speed camera with a frequency of 1000 frames per second, followed by a study of the affected targets by routine and modern methods (scanning electron microscopy and energy dispersion analysis) were performed. Established results showed that fragments of projectile that overcame an obstacle and secondary projectiles have a rather stable zoning distribution behind an obstacle at a distance up to 2.

[Historical aspects, current state and problematic issues of forensic medical examination of a gunshot blunt trauma].

The data of the world literature characterizing the forensic aspects of blunt trauma are generalized and systematized. The issues related to the morphology of damage caused after overcoming an obstacle made of various materials by a bullet, the trajectory of a firearm projectile after overcoming an obstacle, the deformation of a bullet, the transfer of fragments of an obstacle by a bullet, the determination of the distance to the target located behind the damaged barrier, the study of the strength properties of individual human armor protection, the nature of the release of particles of an obstacle. The current state of forensic medical examination of blunt trauma is considered, problems and promising directions of their solution are identified.