Publications by authors named "M P Severs"
Paucity of gastrointestinal plasma cells in common variable immunodeficiency.
Curr Opin Allergy Clin Immunol
December 2024
Purpose Of Review: Common variable immunodeficiency enteropathy (CVID-E) is a noninfectious complication of CVID caused by chronic inflammation of the gastrointestinal (GI) tract. Based on literature, a paucity or lack of plasma cells, although not obligatory for diagnosis, is a pathognomonic feature of CVID and more frequent in CVID-E. However, there is no consensus on standardized histopathological analysis of this feature in biopsies.
View Article and Find Full Text PDFBackground: Narrow band green light (NbGL) has been shown to relieve headache in small numbers of subjects but large-scale real-world assessments are lacking. The goal of this prospective, observational, open-label, real world study was to determine whether treatment with NbGL during the ictal phase of migraine, improves patients' perception of their headache, photophobia, anxiety and same-night sleep.
Methods: The study was conducted in purchasers of the NbGL Lamp in two phases.
Article Synopsis
- * Researchers analyzed data from two large studies, finding that male patients generally had earlier onset of CD and more severe disease locations, while female patients had more extraintestinal manifestations (EIMs).
- * Despite these differences in disease characteristics, the study concluded that there were no major variations in treatment management or healthcare costs between male and female IBD patients.
Background And Aims: The number of patients with inflammatory bowel disease [IBD], of non-Caucasian descent in Western Europe, is increasing. We aimed to explore the impact of ethnicity and country of birth on IBD phenotype.
Methods: IBD patients treated in the eight University Medical Centers in The Netherlands [Dutch IBD Biobank] were divided into two groups according to their ethnicity: 1] Caucasian patients of Western and Central European descent [CEU]; and 2] patients of non-Caucasian descent [non-CEU].
Article Synopsis
- - The study focused on identifying predictors of nonadherence to medical therapy in patients with inflammatory bowel disease (IBD) by assessing various factors over 2.5 years using questionnaires and logistic regression analysis.
- - Among 2,612 patients (1,558 with Crohn's disease and 1,054 with ulcerative colitis), about 12.1% (CD) and 13.3% (UC) were found to be nonadherent to their medication, often involving specific treatments like mesalazine and budesonide.
- - Key predictors of future nonadherence included younger age at diagnosis, the presence of disease flares, feelings of anxiety or depression, and previous nonadherence, suggesting