Publications by authors named "M P Seed"
The adult mammalian heart is unable to undergo cardiac repair, limiting potential treatment options after cardiac damage. However, the fetal heart is capable of cardiac repair. In preparation for birth, cardiomyocytes (CMs) undergo major maturational changes that include exit from the cell cycle, hypertrophic growth, and mitochondrial maturation.
View Article and Find Full Text PDFProgramming effects of maternal undernutrition on fetal metabolic and cardiovascular systems are well elucidated, yet a detailed characterization of maternal haemodynamics is not available. This study used comprehensive cardiovascular magnetic resonance (CMR) imaging to quantify maternal haemodynamics after 29 days (111-140 days) of late-gestation undernutrition (LGUN) in pregnant sheep. Control ewes received 100% of metabolizable energy requirements (MERs, n = 15), whereas LGUN ewes were globally nutrient restricted to 50% MER (n = 18), with a subset of fetuses undergoing continuous glucose infusion (LGUN + G, n = 6/18).
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- A newborn with a rare heart condition was found to have an unusual liver blood flow pattern during a CT scan that was initially thought to be a blood clot.
- The case highlights how the baby's unique anatomy affects liver blood flow distribution, leading to the misinterpretation of imaging results.
- Gaining a clearer understanding of these hepatic perfusion abnormalities can help medical professionals correctly identify similar cases in the future, preventing misdiagnosis and extra tests.
Article Synopsis
- A study was conducted to assess the effectiveness of a specific MRI technique (delayed 3D IR FLASH) in evaluating the lower airways of children during routine cardiovascular magnetic resonance imaging.
- The study included 180 pediatric patients, with a high image quality rating and visibility of lower airways; around 21% of patients showed lower airway abnormalities, particularly among those with congenital heart disease.
- The results suggest that this MRI method is highly reliable and effective for viewing lower airway anatomy, enhancing the potential for identifying issues in children with heart conditions.
Article Synopsis
- Long-term enlargement of the aortic arch after reconstruction in patients with hypoplastic left heart syndrome (HLHS) was studied using measurements from 50 patients who underwent Fontan completion.* -
- Over time, the dimensions of the aortic arch increased significantly after reconstruction, with peak enlargement typically occurring around 7 to 12 months post-surgery, followed by a gradual decline in growth into adolescence.* -
- Both Norwood and hybrid surgical strategies resulted in similar patterns of aortic arch enlargement, suggesting the need to investigate surgical factors that could optimize growth outcomes.*