Quality of Life After Locoregional Treatment in Women with De Novo Metastatic Breast Cancer: A Systematic Review and Meta-Analysis.

Introduction: Primary site locoregional treatment (LRT) of metastatic breast cancer has been performed and evaluated with the aim to improve survival, prevent complications, and alleviate local symptoms. As some studies fail to show a survival benefit, the quality of life is important to consider when deciding on LRT. The aim of this study was to evaluate and quantify the impact of LRT on the quality of life of patients with de novo metastatic breast cancer (dnMBC) through a systematic review of the literature and a meta-analysis.

Engineering Symmetry Breaking Interfaces by Nanoscale Structural-Energetics in Orthorhombic Perovskite Thin Films.

The atomic configuration of phases and their interfaces is fundamental to materials design and engineering. Here, we unveil a transition metal oxide interface, whose formation is driven by energetic influences─epitaxial tensile strain versus oxygen octahedra connectivity─that compete in determining the orientation of an orthorhombic perovskite film. We study this phenomenon in layers of LaVO grown on (101) DyScO, using atomic-resolution scanning transmission electron microscopy to measure intrinsic markers of orthorhombic symmetry.

Integrating information from off-board sensors into the submarine control room: workload, situation awareness, and performance consequences.

Off-board sensors have the potential to provide submarine control rooms with otherwise inaccessible information to supplement data gathered by on-board sensors. Using Uninhabited Aerial Vehicles (UAVs) as a representative test case, we examined how team performance, workload and situation awareness were impacted by receiving raw, compared to processed, sensor data from one or two off-board UAVs. Sixteen teams of three participants were trained to compile a tactical picture and to complete missions.

Characterizing Metabolic Shifts in Septic Murine Kidney Tissue Using 2P-FLIM for Early Sepsis Detection.

In this study, thin mouse kidney sections from healthy mice and those infected leading to acute and chronic sepsis were examined with two-photon excited fluorescence lifetime imaging (2P-FLIM) using the endogenous fluorescent coenzymes nicotinamide adenine dinucleotide (NADH) and flavin adenine dinucleotide (FAD). The results presented show that this approach is a powerful tool for investigating cell metabolism in thin tissue sections. An adapted measurement routine was established for these samples by performing a spectral scan, identifying a combination of two excitation wavelengths and two detection ranges suitable for detailed scan images of NADH and FAD.

Attenuated growth factor signaling during cell death initiation sensitizes membranes towards peroxidation.

Cell death programs such as apoptosis and ferroptosis are associated with aberrant redox homeostasis linked to lipid metabolism and membrane function. Evidence for cross-talk between these programs is emerging. Here, we show that cytotoxic stress channels polyunsaturated fatty acids via lysophospholipid acyltransferase 12 into phospholipids that become susceptible to peroxidation under additional redox stress.