Atria Depolarization in Rats with Alcoholic Cardiomyopathy.

Chronotopography of atrial subepicardium depolarization has been studied in a rat model of alcoholic cardiomyopathy. Formation of independent sources of initial atrial activity has been detected in the right and left atria. These sources induced the formation of several depolarization fronts that propagated autonomously, and this can be regarded as the cause of atrial arrhythmia.

[Intramural chronotopography of depolarization of myocardium of heart ventricles of pig (Sus scrofa domesticus)].

Sequence of depolarization of myocardium of pig heart ventricles was studied by the method of multichannel synchronous cardioelectrotopography. There is established formation of areas of early depolarization in subendocardium of interventricular septum and in the base of left ventricle papillary muscles; of multiple foci--in the depth of walls; of areas of late depolarization--in subepicardium of the left ventricle dorsolateral side. As compared with other species of ungulate animals (reindeer and sheep, in pig heart ventricles, differences are revealed in locations of early and late depolarization, a breakdown of the excitation wave into subepicardium.

Comparison of propagation of atrial excitation with the cardiopotential distribution on the body surface of hypertensive rats.

Objective: Arterial hypertension is associated with the risk of developing atrial arrhythmia. This research was aimed at studying the sequence of depolarization along the atrial epicardium and formation of the cardioelectric field on the body surface of hypertensive rats.

Methods: The study was carried out on eleven ISIAH rats (with hereditary stress-induced hypertension).