Publications by authors named "M P Paratore"
The aim of this study was to investigate the accuracy in fibrosis staging of a novel shear wave elastography (SWE) device (S-Shearwave Imaging by Samsung) and a previously validated 2D-SWE by Supersonic Imagine (SSI) in patients with biopsy proven metabolic dysfunction-associated steatotic liver disease (MASLD). This prospective study included 75 consecutive patients with MASLD who underwent liver biopsy for suspected MASH. All patients underwent S-Shearwave Imaging by Samsung and 2D-SWE with SSI on the same day of liver biopsy.
View Article and Find Full Text PDFPancreatic cancer is one of the most aggressive cancers with a very poor 5-year survival rate and reduced therapeutic options when diagnosed in an advanced stage. The dismal prognosis of pancreatic cancer has guided significant efforts to discover novel biomarkers in order to anticipate diagnosis, increasing the population of patients who can benefit from curative surgical treatment. CA 19-9 is the reference biomarker that supports the diagnosis and guides the response to treatments.
View Article and Find Full Text PDFBackground: Pneumomediastinum (PNM) is a severe complication in COVID-19 patients, potentially exacerbating morbidity and requiring heightened clinical attention. This study aims to identify risk factors, clinical characteristics, and outcomes associated with PNM in COVID-19 patients hospitalized for respiratory failure in our institution.
Methods: Among 4513 patients admitted in our institution and testing positive for COVID-19 infection during the peak of the COVID-19 pandemic in Italy (1 March 2020 to 31 July 2020), we conducted a single-center, retrospective case-control study focusing our analysis on those with severe disease (respiratory failure).
Article Synopsis
- Pancreatic cancer (PC) is a leading cause of cancer-related deaths, known for its aggressive nature and late detection due to subtle early symptoms, as well as ineffective treatments.
- The tumor's complex environment plays a significant role in how it develops, affecting metabolism, cell growth, metastasis, and immune response.
- Advances in omics sciences, such as metabolomics and genomics, are improving our ability to classify cancer subtypes and personalize treatments, although challenges like complexity, cost, and expertise still hinder their widespread clinical use.
Article Synopsis
- - The pancreatic nervous system is vital for both endocrine and exocrine functions, but diseases can disrupt its normal activities, leading to changes like increased nerve density and neural hypertrophy, especially highlighted in pancreatic cancer.
- - Pain management in pancreatic diseases is challenging due to the unique characteristics of pancreatic pain and the need for personalized treatment approaches, with analgesic therapy being fundamental.
- - Ongoing research into neuroplasticity and new neuromodulatory drugs is essential for understanding pancreatic diseases and improving treatment strategies, indicating a significant need for further studies in this area.