Publications by authors named "M P Pakarinen"
Primary sclerosing cholangitis in children with inflammatory bowel disease: An ESPGHAN position paper from the Hepatology Committee and the IBD Porto group.
J Pediatr Gastroenterol Nutr
December 2024
Objective: We aimed to provide an evidence-supported approach to diagnose, monitor, and treat children with inflammatory bowel disease (IBD) and primary sclerosing cholangitis (PSC).
Methods: The core group formulated seven PICO-structured clinical questions. A systematic literature search from inception to December 2022 was conducted by a medical librarian using MEDLINE and EMBASE.
Objective: The aim was to assess fertility, sexual function and sexual quality of life in males with Hirschsprung's disease (HSCR) in the Nordic countries with a cross-sectional study using self-reported validated questionnaires.
Summary Background Data: Data on fertility and sexual function in males with HSCR are limited.
Methods: This multi-center study targeted all males born between 1970-2003 who underwent pull-through surgery at a pediatric surgery center in Sweden, Denmark, Norway, or Finland.
Objectives: Children with short bowel syndrome (SBS) are at increased risk of micronutrient deficiencies. We aimed to study weaning off parenteral nutrition (PN) as a risk factor for vitamin and trace element deficiencies and growth deficit.
Methods: Children born between 2010 and 2019, treated for SBS in Helsinki University Hospital, were followed for their nutrition, growth, and vitamin and trace element biochemical status.
Article Synopsis
- - Anorectal malformations (ARM) are rare congenital defects occurring in about 3.32 per 10,000 pregnancies, involving a range of issues from mild anal canal displacement to severe fusion of the anorectum, vagina, and urethra.
- - The developmental basis of ARM stems from improper septation of the hindgut during early pregnancy, with most cases being non-syndromic and lacking clear genetic causes.
- - Surgical correction, primarily through posterior sagittal anorectoplasty since 1982, is common, but there is a need for further improvements in surgery outcomes, prenatal detection, and understanding the psychosocial impacts on patients.
Our research laboratory has a longstanding interest in developmental disorders and embryonic tumors, and recent efforts have focused on the pathogenesis of pediatric liver tumors. This review focuses on hepatoblastoma (HB), the most common pediatric liver malignancy. Despite advances in treatment, patients with metastatic HB have a poor prognosis, and survivors often have permanent side effects attributable to chemotherapy.
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