Observation of edge bound states in the continuum at truncated silicon pillar photonic crystal.

Bound states in the continuum are optical modes with extremely high-quality factors and narrow resonances, which exist in the dispersion spectrum of the radiative region above the light line. A unique bound state in the continuum is supported at the edge of truncated photonic crystals, which is a type of a Fabry-Pérot type bound state in the continuum, but has never been observed in experiments. Here, we demonstrate the bound states in the continuum supported at the edge array of silicon (Si) pillars whose diameter is bigger than that of the rest of a Si-pillar two-dimensional photonic crystal.

Liposome-encapsulated aprotinin biodistribution in mice: Side-by-side comparison with free drug formulation.

Injuries of the respiratory system caused by viral infections (e.g., by influenza virus, respiratory syncytial virus, metapneumovirus, or coronavirus) can lead to long-term complications or even life-threatening conditions.

Albumin incorporation into recognising layer of HER2-specific magnetic nanoparticles as a tool for optimal targeting of the acidic tumor microenvironment.

Cancer is unquestionably a global healthcare challenge, spurring the exporation of novel treatment approaches. In recent years, nanomaterials have garnered significant interest with the greatest hopes for targeted nanoformulations due to their cell-specific delivery, improved therapeutic efficacy, and reduced systemic toxicity for the organism. The problem of successful clinical translation of nanoparticles may be related to the fact that most in vitro tests are performed at pH values of normal cells and tissues, ranging from 7.

A do-it-yourself benchtop device for highly scalable flow synthesis of protein-based nanoparticles.

Synthesis of nanoparticles is typically carried out in batch procedures, which offer limited control of parameters, and a narrow range of possible batch volumes. In contrast, flow synthesis systems, usually having a microfluidic chip as a crucial part, are devoid of these drawbacks. However, large scale devices - millifluidic systems - may offer several advantages over microfluidic systems, such as easier and cheaper production, enhanced throughput, and reduced channel clogging.

Carbene-coated metal nanoparticles for in vivo applications.

N-Heterocyclic carbenes (NHC) are well-recognized ligands of choice for preparing robust transition metal species. However, their use for fabrication of biomedically relevant nanoparticles has been limited to the synthesis of non-targeted particles showing increased tolerance to different aqueous coagulants. In this work, the first example of carbene-coated metal nanoparticles suitable for in vivo applications is presented.