[Clinical and genetic features of APC- and MYH-mutation-negative patients with multiple polyposis of large bowel that tested by conventional methods].

The genealogic analysis, molecular and clinical investigations has been carried out in 19 probands with multiple colorectal adenomas (approximately 100 or more). Twelve of these patients (63.1%) were APC and MYH mutation-negative.

[Genetic counseling and prognosis of the development of complications in patients with syndromes of hereditary polyposis of the colon].

Physical examinations, genealogic analysis and genetic consulting were done for 14 probands and their family members with most frequent syndromes of hereditary polyposis of large bowel during 4 generations. These syndromes include familial adenomatous polyposis, Gardner syndrome and Peutz-Jeghers syndrome. 46 relatives of probands with the same pathology were affected (from 1 to 9 of affected relatives within families).

[Peculiarities of cytogenetic changes in different types of myelodysplastic syndrome].

We carried out the cytogenetic investigation of bone marrow aspirate from 32 patients with different types of MDS. The patients were from 8 regions of Ukraine. 11 patients had abnormal karyotype, and the transformation to AML were observed in 5 of them (45.

[The spectrum of cytogenetic chages in polyps of the large intestine with different histologic structure].

Cytogenetical study ofcolorectal polyps of different histological structures from 54 patients has been carried out. Domination of diploid karyotypes was shown. Abnormal karyotypes were found in 17 (31,5%) polyps: the most frequent anomalies were in adenoma while in hamartomatous polyps they were absent.

[Prognostic significance of additional chromosomal abnormalities in Ph positive bone marrow cells in chronic myeloid leukemia].

We studied the prognostic significance of combination of different chromosomal abnormalities and genomic mutations in Ph+ chronic myeloid leukemia patients. In general 49 cytogenetic analyses of bone marrow aspirate from 35 patients (11 of these observed in dynamics) have been carried out. The additional chromosome changes were found in 25.