Histological reactions of porous tip endocardial electrodes implanted in sheep.

The tissue reaction caused by a sintered tip electrode is compared with that of a platinum-iridium tip electrode in a work which employs implantation in sheep and follow-up of the implant for up to 90 days. Clinical tests and anatomo-pathological examination of the histological sections were performed. The results show a remarkably rapid fixation to the heart for the porous electrode with formation of limited inflammatory process, a thin fibrous capsule and modest alteration of the endocardial tissue.

Use of uncoated activated carbon hemoperfusion in acute poisoning: in vitro studies.

In acute poisoning the main purpose of any therapeutic approach is a rapid removal of the drug or poison from body tissues. This approach suggested to undertake a study for the development of an uncoated activated carbon hemoperfusion column suitable for acute poisoning. Th clearances were significantly superior compared with a similar device manufactured using coated carbon.

[Biocompatibility and quality control of pacemaker (author's transl)].

The Authors examine the functional, toxicological and pharmacological controls routinely performed on materials and on the finished products. They propose a biocompatibility protocol for screening materials, and they compare Italian regulations on quality control and good manufacturing practice of medical devices with foreign regulations.