Publications by authors named "M P Kutyreva"
Article Synopsis
- * The study introduces third generation PAMAM dendrimers with a thiacalixarene core in three different conformations, found to effectively bind and compact DNA while showing improved binding efficiency with generations.
- * The findings suggest that the structural design of these dendrimers can lower hemotoxicity and potentially simplify the development of new, cost-effective drug delivery systems in nanomedicine.
Article Synopsis
- Researchers discovered that Lactiplantibacillus plantarum 8p-a3, a probiotic strain, shows significant changes in its extracellular membrane vesicles when developing resistance to antibiotics (amoxicillin and clarithromycin).
- These changes are linked to large genome rearrangements and alterations in how the strain responds to various antimicrobials, as well as an increase in virulence factors.
- The study highlights how the structure and function of these vesicles may adapt to help the bacteria survive under the pressure of antibiotics, aiding in the understanding of probiotic safety and effectiveness.
Cell therapy is at the forefront of biomedicine in oncology and regenerative medicine. However, there are still significant challenges to their wider clinical application such as limited efficacy, side effects, and logistical difficulties. One of the potential approaches that could overcome these problems is based on extracellular vesicles (EVs) as a cell-free therapy modality.
View Article and Find Full Text PDFA method for the design and synthesis of a metallopolymer composite (CoNP) based on cobalt nanoparticles using the hyperbranched polyol process was developed. It was shown that hyperbranched polyester polyols in a melted state can be both a reducing agent and a stabilizer of metal nanoparticles at the same time. The mechanism of oxidation of hyperbranched polyol was studied using diffuse reflectance IR spectroscopy.
View Article and Find Full Text PDFFor the first time, metal-polymer complexes have been synthesized using hyperbranched polyester polyfumaratomaleate as a matrix, the structure of which has been established by H NMR, IR, electron spectroscopy, and elemental analysis methods. The formation of complexes with Gd(III) and Dy(III) ions involving fumarate and maleate groups of the polyester was proved by IR and electron spectroscopy methods. It was established that the structure of the coordination units has the form of a square antiprism.
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