Publications by authors named "M P Kent"
Engineered monoclonal antibodies have proven to be highly effective therapeutics in recent viral outbreaks. However, despite technical advancements, an ability to rapidly adapt or increase antibody affinity and by extension, therapeutic efficacy, has yet to be fully realized. We endeavored to stand-up such a pipeline using molecular modeling combined with experimental library screening to increase the affinity of F5, a monoclonal antibody with potent neutralizing activity against Venezuelan Equine Encephalitis Virus (VEEV), to recombinant VEEV (IAB) E1E2 antigen.
View Article and Find Full Text PDFBackground: The coexistence of transthyretin cardiac amyloidosis (ATTR-CA) and aortic stenosis (AS) is increasingly recognized, but the clinical consequences are unclear. We aimed to characterize clinical outcomes in AS plus ATTR-CA compared with only AS or ATTR-CA.
Methods And Results: In a retrospective cohort study, patients with AS only, ATTR-CA only, or AS plus ATTR-CA were identified using all-payer claims data (2015-2021).
Objective: To describe the clinical characteristics, treatments, complications, and outcomes in dogs with nasal planum squamous cell carcinoma (SCC) undergoing local treatment.
Methods: A retrospective, multi-institutional study was performed. Medical records were searched to identify dogs diagnosed with nasal planum SCC.
Article Synopsis
- The study investigates the role of the hippocampus (HPC) and amygdala in memory formation, particularly focusing on retrograde amnesia that occurs after HPC disruption.
- Findings reveal that damage to the HPC does not affect conditioned place preference (CPP) tasks, which rely on the basolateral amygdala, suggesting that not all learning tasks require HPC involvement.
- Additional experiments using the Morris water task indicate that while HPC damage impairs performance, other memory networks can't fully compensate when certain training methods are used, highlighting the complexity of memory processing.