Publications by authors named "M P J van Boxtel"
Background: Hearing loss (HL) and visual loss (VL) are recently identified as promising dementia risk factors, but long-term studies with adequate control of other modifiable dementia risk factors are lacking. This 25-year follow-up study investigated the association between objectively measured HL and VL with cognitive decline and incident dementia.
Methods: 1823 participants (age 24-82 years) of the Maastricht Aging Study were assessed at baseline, 6, 12 and 25 years.
Background: We aimed to develop risk tools for dementia, stroke, myocardial infarction (MI), and diabetes, for adults aged ≥ 65 years using shared risk factors.
Methods: Data were obtained from 10 population-based cohorts (N = 41,755) with median follow-up time (years) for dementia, stroke, MI, and diabetes of 6.2, 7.
Article Synopsis
- The study explores the relationship between air pollution and its impact on cognitive functioning and brain health, given the rise in dementia cases and a lack of cures.
- It involved 4,002 participants from The Maastricht Study, analyzing various brain integrity markers and cognitive abilities while considering their residential air pollution exposure.
- Results showed no significant links between air pollution and cognitive performance or most brain markers, but a curvilinear relationship was noted where both low and high exposures were related to reduced grey matter volume.
Background: The "LIfestyle for BRAin health" (LIBRA) index was recently updated with three new modifiable factors: hearing impairment, social contact, and sleep (LIBRA2), but has not yet been validated.
Objective: Comparison of the performance of both LIBRA versions in predicting dementia risk.
Methods: Longitudinal data from the English Longitudinal Study of Ageing (ELSA) and the Maastricht Aging Study (MAAS) were used.
Background: Socioeconomic inequalities in cognitive impairment may partly act through structural brain damage and reduced connectivity. This study investigated the extent to which the association of early-life socioeconomic position (SEP) with later-life cognitive functioning is mediated by later-life SEP, and whether the associations of SEP with later-life cognitive functioning can be explained by structural brain damage and connectivity.
Methods: We used cross-sectional data from the Dutch population-based Maastricht Study (n = 4,839; mean age 59.